Dataset Information

Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection.

ABSTRACT:

Purpose

This prospective study aimed to examine the combined effect of viral load and alcohol consumption on the risk of persistent high-risk (HR) human papillomavirus (HPV) infection.

Methods

Among women undergoing health screening between 2002 and 2011 at the National Cancer Center, 284 and 122 women with HR-HPV infection and cytological findings of low-grade squamous intraepithelial or lower-grade lesions were followed up for 1 and 2 years, respectively. Multivariate logistic regression analysis was performed, and the relative excess risk due to interaction (RERI) and synergy index (S) were calculated.

Results

Among drinkers, the risks of 1-year (odds ratio [OR] 4.09, 95% confidence interval [CI] 2.05-8.18) and 2-year persistence (OR 8.08, CI 2.36-27.6) were significantly higher for high HPV loads than for low HPV loads; this association was not seen for non-drinkers. The risks for 1-year (OR 4.14, CI 1.89-9.05) and 2-year persistence (OR 6.61, CI 2.09-20.9) were significantly higher in subjects with a high HPV load who were also drinkers than in those who were non-drinkers. A high HPV load together with a longer drinking duration or higher alcohol consumption was associated with increased risks of 1-year (OR 3.07, CI 1.40-6.75 or OR 2.05, CI 0.87-4.83) and 2-year persistence (OR 6.40, CI 1.72-23.8 or OR 4.14, CI 1.18-14.6). The synergistic effect of alcohol consumption and HR-HPV load was stronger on the risk of 2-year persistence (RERI?=?3.26, S?=?2.38) than on the risk of 1-year persistence (RERI?=?1.21, S?=?1.63).

Conclusions

The synergistic effect of HR-HPV load and alcohol consumption was associated with the risk of HR-HPV persistence and was stronger for longer-term HR-HPV infection. Limiting alcohol consumption might be an important measure to prevent the development of cervical cancer in women with a high HR-HPV load.

SUBMITTER: Oh HY

PROVIDER: S-EPMC4139267 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection.

Oh Hea Young HY Seo Sang-Soo SS Kim Mi Kyung MK Lee Dong Ock DO Chung Youn Kyung YK Lim Myong Cheol MC Kim Joo-Young JY Lee Chan Wha CW Park Sang-Yoon SY

PloS one 20140820 8

<h4>Purpose</h4>This prospective study aimed to examine the combined effect of viral load and alcohol consumption on the risk of persistent high-risk (HR) human papillomavirus (HPV) infection.<h4>Methods</h4>Among women undergoing health screening between 2002 and 2011 at the National Cancer Center, 284 and 122 women with HR-HPV infection and cytological findings of low-grade squamous intraepithelial or lower-grade lesions were followed up for 1 and 2 years, respectively. Multivariate logistic r ...[more]

PMID: 25140695

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Dataset Information

Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection.

Purpose

Methods

Results

Conclusions

Publications

Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection.

Similar Datasets

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