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WNT16B from ovarian fibroblasts induces differentiation of regulatory T cells through ?-catenin signal in dendritic cells.

ABSTRACT: Treatment for cancer can induce a series of secreted factors into the tumor microenvironment, which can affect cancer progression. Wingless-type MMTV (mouse mammary tumor virus) integration site 16B (WNT16B) is a new member of the WNT family and has been reported to play growth-related roles in previous studies. In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation. We also demonstrated that fibroblast-derived WNT16B could result in accumulation of ?-catenin in dendritic cells and secretion of interleukin-10 (IL-10) and transforming growth factor beta (TGF-?), which contributed to the differentiation of regulatory T cells in a co-culture environment. These results shed light on the roles of WNT16B in immune regulation, especially in regard to cancer treatment.

SUBMITTER: Shen CC 

PROVIDER: S-EPMC4139882 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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WNT16B from ovarian fibroblasts induces differentiation of regulatory T cells through β-catenin signal in dendritic cells.

Shen Cong-Cong CC   Kang Yu-Huan YH   Zhao Ming M   He Yi Y   Cui Dan-Dan DD   Fu Yu-Yin YY   Yang Ling-Lin LL   Gou Lan-Tu LT  

International journal of molecular sciences 20140721 7

Treatment for cancer can induce a series of secreted factors into the tumor microenvironment, which can affect cancer progression. Wingless-type MMTV (mouse mammary tumor virus) integration site 16B (WNT16B) is a new member of the WNT family and has been reported to play growth-related roles in previous studies. In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs  ...[more]

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