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ABSTRACT:
SUBMITTER: Furukawa K
PROVIDER: S-EPMC4140405 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Furukawa Kazuhiro K Gu Hongzhou H Sudarsan Narasimhan N Hayakawa Yoshihiro Y Hyodo Mamoru M Breaker Ronald R RR
ACS chemical biology 20120619 8
Riboswitches for the bacterial second messenger c-di-GMP control the expression of genes involved in numerous cellular processes such as virulence, competence, biofilm formation, and flagella synthesis. Therefore, the two known c-di-GMP riboswitch classes represent promising targets for developing novel modulators of bacterial physiology. Here, we examine the binding characteristics of circular and linear c-di-GMP analogues for representatives of both class I and II c-di-GMP riboswitches derived ...[more]