Ontology highlight
ABSTRACT:
SUBMITTER: Wood S
PROVIDER: S-EPMC3356476 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
ACS chemical biology 20120313 5
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger important for physiologic adaptation and virulence. Class-I c-di-GMP riboswitches are phylogenetically widespread and thought to mediate pleiotropic genetic responses to the second messenger. Previous studies suggest that the RNA aptamer domain switches from an extended free state to a compact, c-di-GMP-bound conformation in which two helical stacks dock side-by-side. Single molecule fluorescence resonance energy transfer (smFRET) exp ...[more]