Ontology highlight
ABSTRACT:
SUBMITTER: Chou CF
PROVIDER: S-EPMC4141372 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Chou Chu-Fang CF Lin Yi-Yu YY Wang Hsu-Kun HK Zhu Xiaolin X Giovarelli Matteo M Briata Paola P Gherzi Roberto R Garvey W Timothy WT Chen Ching-Yi CY
Diabetes 20140410 9
Brown adipose tissue oxidizes chemical energy for heat generation and energy expenditure. Promoting brown-like transformation in white adipose tissue (WAT) is a promising strategy for combating obesity. Here, we find that targeted deletion of KH-type splicing regulatory protein (KSRP), an RNA-binding protein that regulates gene expression at multiple levels, causes a reduction in body adiposity. The expression of brown fat-selective genes is increased in subcutaneous/inguinal WAT (iWAT) of Ksrp( ...[more]