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Gold nanoparticles in breast cancer treatment: promise and potential pitfalls.

ABSTRACT: Despite remarkable achievements in the treatment of breast cancer, some obstacles still remain. Gold nanoparticles may prove valuable in addressing these problems owing to their unique characteristics, including their enhanced permeability and retention in tumor tissue, their light absorbance and surface plasmon resonance in near-infrared light, their interaction with radiation to generate secondary electrons, and their ability to be conjugated with drugs or other agents. Herein, we discuss some basic concepts of gold nanoparticles, and early results from studies regarding their use in breast cancer, including toxicity and side effects. We also discuss these particles' potential clinical applications.

SUBMITTER: Lee J

PROVIDER: S-EPMC4142062 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Gold nanoparticles in breast cancer treatment: promise and potential pitfalls.

Lee Jihyoun J Chatterjee Dev Kumar DK Lee Min Hyuk MH Krishnan Sunil S

Cancer letters 20140217 1

Despite remarkable achievements in the treatment of breast cancer, some obstacles still remain. Gold nanoparticles may prove valuable in addressing these problems owing to their unique characteristics, including their enhanced permeability and retention in tumor tissue, their light absorbance and surface plasmon resonance in near-infrared light, their interaction with radiation to generate secondary electrons, and their ability to be conjugated with drugs or other agents. Herein, we discuss some ...[more]

PMID: 24556077

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