Ontology highlight
ABSTRACT:
SUBMITTER: Oakes PW
PROVIDER: S-EPMC4142236 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Oakes Patrick W PW Banerjee Shiladitya S Banerjee Shiladitya S Marchetti M Cristina MC Gardel Margaret L ML
Biophysical journal 20140801 4
Cells generate mechanical stresses via the action of myosin motors on the actin cytoskeleton. Although the molecular origin of force generation is well understood, we currently lack an understanding of the regulation of force transmission at cellular length scales. Here, using 3T3 fibroblasts, we experimentally decouple the effects of substrate stiffness, focal adhesion density, and cell morphology to show that the total amount of work a cell does against the substrate to which it is adhered is ...[more]