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Microvortex for focusing, guiding and sorting of particles.

ABSTRACT: We report a microvortex manipulator (MVM) that is a passive, scalable system with great potential for the manipulation and separation of particulate samples in microfluidic environments. The movement of particles is determined by a unique combination of helical flow, buoyant, and gravitational forces. Helical flows are induced by topographically patterned microchannel surfaces, which have previously been used for molecular mixing in microfluidic devices. We illustrate the mechanism of MVM and its applications in passive focusing of beads and cells into parallel streams and guiding of particles and cells. We also explore the application of the unique density-selectivity of microvortex focusing and successfully sort a mixture of two bead populations whose density difference is as small as 0.1 g cm(-3).

SUBMITTER: Hsu CH

PROVIDER: S-EPMC4142319 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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Microvortex for focusing, guiding and sorting of particles.

Hsu Chia-Hsien CH Di Carlo Dino D Chen Chihchen C Irimia Daniel D Toner Mehmet M

Lab on a chip 20081030 12

We report a microvortex manipulator (MVM) that is a passive, scalable system with great potential for the manipulation and separation of particulate samples in microfluidic environments. The movement of particles is determined by a unique combination of helical flow, buoyant, and gravitational forces. Helical flows are induced by topographically patterned microchannel surfaces, which have previously been used for molecular mixing in microfluidic devices. We illustrate the mechanism of MVM and it ...[more]

PMID: 19023476

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