Ontology highlight
ABSTRACT:
SUBMITTER: Pantazopoulou A
PROVIDER: S-EPMC4142615 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Pantazopoulou Areti A Pinar Mario M Xiang Xin X Peñalva Miguel A MA
Molecular biology of the cell 20140618 16
The mechanism(s) by which proteins traverse and exit the Golgi are incompletely understood. Using Aspergillus nidulans hyphae, we show that late Golgi cisternae undergo changes in composition to gradually lose Golgi identity while acquiring post-Golgi RabE(RAB11) identity. This behavior of late Golgi cisternae is consistent with the cisternal maturation model. Post-Golgi RabE(RAB11) carriers travel to, and accumulate at, the apex, indicating that fusion is rate limiting for exocytosis. These car ...[more]