Dataset Information
A cooperative N-heterocyclic carbene/chiral phosphate catalysis system for allenolate annulations.
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ABSTRACT:
SUBMITTER: Lee A
PROVIDER: S-EPMC4142640 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
A cooperative N-heterocyclic carbene/chiral phosphate catalysis system for allenolate annulations.
Angewandte Chemie (International ed. in English) 20140604 29
The highly enantioselective NHC-catalyzed [3+2] annulation reaction with α,β-alkynals and α-ketoesters has been developed. A new mode of cooperative catalysis involving the combination of a chiral Brønsted acid and a C1-symmetric biaryl saturated-imidazolium precatalyst was required to generate the desired γ-crotonolactones in high yields and levels of enantioselectivity. ...[more]