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A Cooperative N-Heterocyclic Carbene/Palladium Catalysis System.

ABSTRACT: N-heterocyclic carbenes (NHC) have been extensively studied as organocatalysts and ligands for transition metals, but the successful integration of NHCs and late transition metals in cooperative catalysis remains an underexplored area. We have developed a cooperative palladium-catalyzed allylation of NHC-activated aldehydes to access a variety of 3-allyl dihydrocoumarin derivatives. Kinetic experiments support a cooperative pathway for this transformation.

SUBMITTER: Liu K 

PROVIDER: S-EPMC4212655 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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A Cooperative N-Heterocyclic Carbene/Palladium Catalysis System.

Liu Kun K   Hovey M Todd MT   Scheidt Karl A KA  

Chemical science 20141001 10

N-heterocyclic carbenes (NHC) have been extensively studied as organocatalysts and ligands for transition metals, but the successful integration of NHCs and late transition metals in cooperative catalysis remains an underexplored area. We have developed a cooperative palladium-catalyzed allylation of NHC-activated aldehydes to access a variety of 3-allyl dihydrocoumarin derivatives. Kinetic experiments support a cooperative pathway for this transformation. ...[more]

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