Ontology highlight
ABSTRACT:
SUBMITTER: Alipour M
PROVIDER: S-EPMC4142912 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Alipour Mohsen M Zargar Seyed Jalal SJ Safarian Shahrokh S Fouladdel Shamileh S Azizi Ebrahim E Jafargholizadeh Naser N
Iranian journal of cancer prevention 20130101 2
<h4>Background</h4>The Bcl-2 protein family members have known as essential controllersof mitochondrial pathway of apoptosis. Bax has been implicated as potential tumor suppressor in certain solid tumors such as breast and colorectal carcinoma. DNA methylation of promoter associated CpG islands has known as a common mechanism for gene inactivation in tumor cells.<h4>Methods</h4>The Methylation Specific PCR (MSP) has used to find the methylation profile of the bax gene promoter CpG islands in col ...[more]