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Competition between recently potentiated synaptic inputs reveals a winner-take-all phase of synaptic tagging and capture.

ABSTRACT: Canonical models suggest that mechanisms of long-term memory consist of a synapse-specific, protein synthesis-independent induction phase (changes in synaptic weights/temporary tagging of such synapses) and, within adjacent dendritic compartments, a protein synthesis-dependent distribution phase that may accompany or immediately precede induction and whose protein products enable consolidation through synaptic capture. We now report that this distribution phase is competitive in a "winner-take-all" fashion when synapses potentiated at induction compete with each other for plasticity-related proteins. This finding highlights the importance of synaptic competition in creating stable long-lasting memory in neural networks without disruption.

SUBMITTER: Sajikumar S

PROVIDER: S-EPMC4143050 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Competition between recently potentiated synaptic inputs reveals a winner-take-all phase of synaptic tagging and capture.

Sajikumar Sreedharan S Morris Richard G M RG Korte Martin M

Proceedings of the National Academy of Sciences of the United States of America 20140804 33

Canonical models suggest that mechanisms of long-term memory consist of a synapse-specific, protein synthesis-independent induction phase (changes in synaptic weights/temporary tagging of such synapses) and, within adjacent dendritic compartments, a protein synthesis-dependent distribution phase that may accompany or immediately precede induction and whose protein products enable consolidation through synaptic capture. We now report that this distribution phase is competitive in a "winner-take-a ...[more]

PMID: 25092326

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