Ontology highlight
ABSTRACT:
SUBMITTER: Hainline A
PROVIDER: S-EPMC4143711 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Hainline Allison A Alvarez Carolina C Luedtke Alexander A Greco Brian B Beck Andrew A Tintle Nathan L NL
BMC proceedings 20140617 Suppl 1
Until very recently, few methods existed to analyze rare-variant association with binary phenotypes in complex pedigrees. We consider a set of recently proposed methods applied to the simulated and real hypertension phenotype as part of the Genetic Analysis Workshop 18. Minimal power of the methods is observed for genes containing variants with weak effects on the phenotype. Application of the methods to the real hypertension phenotype yielded no genes meeting a strict Bonferroni cutoff of signi ...[more]