Ontology highlight
ABSTRACT:
SUBMITTER: Greco B
PROVIDER: S-EPMC4143675 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Greco Brian B Luedtke Alexander A Hainline Allison A Alvarez Carolina C Beck Andrew A Tintle Nathan L NL
BMC proceedings 20140617 Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo
Pathway analysis approaches for sequence data typically either operate in a single stage (all variants within all genes in the pathway are combined into a single, very large set of variants that can then be analyzed using standard "gene-based" test statistics) or in 2-stages (gene-based p values are computed for all genes in the pathway, and then the gene-based p values are combined into a single pathway p value). To date, little consideration has been given to the performance of gene-based test ...[more]