A 2-step penalized regression method for family-based next-generation sequencing association studies.
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ABSTRACT:
SUBMITTER: Ding X
PROVIDER: S-EPMC4143756 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
A 2-step penalized regression method for family-based next-generation sequencing association studies.
Ding Xiuhua X Su Shaoyong S Nandakumar Kannabiran K Wang Xiaoling X Fardo David W DW
BMC proceedings 20140617 Suppl 1
Large-scale genetic studies are often composed of related participants, and utilizing familial relationships can be cumbersome and computationally challenging. We present an approach to efficiently handle sequencing data from complex pedigrees that incorporates information from rare variants as well as common variants. Our method employs a 2-step procedure that sequentially regresses out correlation from familial relatedness and then uses the resulting phenotypic residuals in a penalized regress ...[more]
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