Enzyme-triggered gelation: targeting proteases with internal cleavage sites.
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ABSTRACT:
SUBMITTER: Bremmer SC
PROVIDER: S-EPMC4143987 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Enzyme-triggered gelation: targeting proteases with internal cleavage sites.
Bremmer Steven C SC McNeil Anne J AJ Soellner Matthew B MB
Chemical communications (Cambridge, England) 20140201 14
A generalizable method for detecting protease activity via gelation is described. A recognition sequence is used to target the protease of interest while a second protease is used to remove the residual residues from the gelator scaffold. Using this approach, selective assays for both MMP-9 and PSA are demonstrated. ...[more]
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