Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC7685735 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Li Hongzhao H Omange Robert W RW Liang Binhua B Toledo Nikki N Hai Yan Y Liu Lewis R LR Schalk Dane D Crecente-Campo Jose J Dacoba Tamara G TG Lambe Andrew B AB Lim So-Yon SY Li Lin L Kashem Mohammad Abul MA Wan Yanmin Y Correia-Pinto Jorge F JF Seaman Michael S MS Liu Xiao Qing XQ Balshaw Robert F RF Li Qingsheng Q Schultz-Darken Nancy N Alonso Maria J MJ Plummer Francis A FA Whitney James B JB Luo Ma M
The Journal of clinical investigation 20201201 12
After over 3 decades of research, an effective anti-HIV vaccine remains elusive. The recently halted HVTN702 clinical trial not only further stresses the challenge to develop an effective HIV vaccine but also emphasizes that unconventional and novel vaccine strategies are urgently needed. Here, we report that a vaccine focusing the immune response on the sequences surrounding the 12 viral protease cleavage sites (PCSs) provided greater than 80% protection to Mauritian cynomolgus macaques against ...[more]