Ontology highlight
ABSTRACT:
SUBMITTER: Pinney JR
PROVIDER: S-EPMC4144416 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Biomaterials 20140718 31
Chronic fibrosis caused by acute myocardial infarction (MI) leads to increased morbidity and mortality due to cardiac dysfunction. We have developed a therapeutic materials strategy that aims to mitigate myocardial fibrosis by utilizing injectable polymeric microstructures to mechanically alter the microenvironment. Polymeric microstructures were fabricated using photolithographic techniques and studied in a three-dimensional culture model of the fibrotic environment and by direct injection into ...[more]