Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC4144729 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Kumar Sachin S Xu Juying J Kumar Rupali Sani RS Lakshmikanthan Sribalaji S Kapur Reuben R Kofron Matthew M Chrzanowska-Wodnicka Magdalena M Filippi Marie-Dominique MD
The Journal of experimental medicine 20140804 9
Neutrophils are the first line of cellular defense in response to infections and inflammatory injuries. However, neutrophil activation and accumulation into tissues trigger tissue damage due to release of a plethora of toxic oxidants and proteases, a cause of acute lung injury (ALI). Despite its clinical importance, the molecular regulation of neutrophil migration is poorly understood. The small GTPase Rap1b is generally viewed as a positive regulator of immune cell functions by controlling bidi ...[more]