Ontology highlight
ABSTRACT:
SUBMITTER: Carman CV
PROVIDER: S-EPMC2094044 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Carman Christopher V CV Sage Peter T PT Sciuto Tracey E TE de la Fuente Miguel A MA Geha Raif S RS Ochs Hans D HD Dvorak Harold F HF Dvorak Ann M AM Springer Timothy A TA
Immunity 20070601 6
Diapedesis is critical for immune system function and inflammatory responses. This occurs by migration of blood leukocytes either directly through individual microvascular endothelial cells (the "transcellular" route) or between them (the "paracellular" route). Mechanisms for transcellular pore formation in endothelium remain unknown. Here we demonstrate that lymphocytes used podosomes and extended "invasive podosomes" to palpate the surface of, and ultimately form transcellular pores through, t ...[more]