Ontology highlight
ABSTRACT:
SUBMITTER: Liang Q
PROVIDER: S-EPMC4144829 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Liang Qin Q Dexheimer Thomas S TS Zhang Ping P Rosenthal Andrew S AS Villamil Mark A MA You Changjun C Zhang Qiuting Q Chen Junjun J Ott Christine A CA Sun Hongmao H Luci Diane K DK Yuan Bifeng B Simeonov Anton A Jadhav Ajit A Xiao Hui H Wang Yinsheng Y Maloney David J DJ Zhuang Zhihao Z
Nature chemical biology 20140216 4
Protein ubiquitination and deubiquitination are central to the control of a large number of cellular pathways and signaling networks in eukaryotes. Although the essential roles of ubiquitination have been established in the eukaryotic DNA damage response, the deubiquitination process remains poorly defined. Chemical probes that perturb the activity of deubiquitinases (DUBs) are needed to characterize the cellular function of deubiquitination. Here we report ML323 (2), a highly potent inhibitor o ...[more]