Dataset Information
Reconstituted USP1, UAF1, FANCI, and mono-ubiquitinated FANCD2
Ontology highlight
ABSTRACT:
SUBMITTER: Martin Luke Rennie
PROVIDER: EMPIAR-11305 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nature structural & molecular biology 20210401 4
Ubiquitin-specific protease 1 (USP1) acts together with the cofactor UAF1 during DNA repair processes to specifically remove monoubiquitin signals. One substrate of the USP1-UAF1 complex is the monoubiquitinated FANCI-FANCD2 heterodimer, which is involved in the repair of DNA interstrand crosslinks via the Fanconi anemia pathway. Here we determine structures of human USP1-UAF1 with and without ubiquitin and bound to monoubiquitinated FANCI-FANCD2. The crystal structures of USP1-UAF1 reveal plast ...[more]