Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4145930 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Li Xue X Zhao Wencong W Yang Hongqi H Zhang Junhong J Ma Jianjun J
Neural regeneration research 20130901 27
Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen speci ...[more]