Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC4146676 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20141001 37
Three haptens have been synthesized with linkers for attachment to carrier macromolecules at either the piperidino-nitrogen or via an introduced 3-amino group. Two of the haptens, with a 2-oxopropyl functionality at either C6, or at both the C3 and C6 positions on the 4,5-epoxymorphinan framework, as well as the third hapten (DiAmHap) with diamido moieties at both the C3 and C6 positions, should be much more stable in solution, or in vivo in a vaccine, than a hapten with an ester in one of those ...[more]