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Synthesis and immunological study of ?-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines.

ABSTRACT: ?-2,9-Di-, tri-, tetra-, and pentasialic acids were prepared and conjugated with a carrier protein. The resultant glycoconjugates elicited robust T cell-mediated immunity in mice. ?-2,9-Trisialic acid was identified as a promising antigen for developing glycoconjugate vaccines against group C Neisseria meningitidis.

SUBMITTER: Liao G 

PROVIDER: S-EPMC4526240 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines.

Liao Guochao G   Zhou Zhifang Z   Guo Zhongwu Z  

Chemical communications (Cambridge, England) 20150601 47

α-2,9-Di-, tri-, tetra-, and pentasialic acids were prepared and conjugated with a carrier protein. The resultant glycoconjugates elicited robust T cell-mediated immunity in mice. α-2,9-Trisialic acid was identified as a promising antigen for developing glycoconjugate vaccines against group C Neisseria meningitidis. ...[more]

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