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Alternative dosage schedules with HPV virus-like particle vaccines.


ABSTRACT: HPV vaccines can prevent multiple cancers in women and men. Difficulties in the cost and completion of the three-dose vaccine series have led to considerations of alternative dose schedules. In clinical trials, three doses given within a 12-month period versus the standard 6-month period yielded comparable results, and immunogenicity appears comparable with two doses in adolescent females compared to the three-dose series in adult females. While the data are generally supportive of moving to a two-dose vaccine schedule among young female adolescents, the adoption of a two-dose vaccine schedule still poses a potential risk to the strength and longevity of the immune response. Public health authorities implementing a two-dose vaccine schedule should devise risk management strategies to minimize the potential impact on cancer prevention.

SUBMITTER: Stanley MA 

PROVIDER: S-EPMC4147727 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Alternative dosage schedules with HPV virus-like particle vaccines.

Stanley Margaret A MA   Sudenga Staci L SL   Giuliano Anna R AR  

Expert review of vaccines 20140707 8


HPV vaccines can prevent multiple cancers in women and men. Difficulties in the cost and completion of the three-dose vaccine series have led to considerations of alternative dose schedules. In clinical trials, three doses given within a 12-month period versus the standard 6-month period yielded comparable results, and immunogenicity appears comparable with two doses in adolescent females compared to the three-dose series in adult females. While the data are generally supportive of moving to a t  ...[more]

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