Ontology highlight
ABSTRACT:
SUBMITTER: Zhao G
PROVIDER: S-EPMC4148195 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Zhao Gang G Dharmadhikari Gitanjali G Maedler Kathrin K Meyer-Hermann Michael M
PLoS computational biology 20140828 8
Increasing evidence of a role of chronic inflammation in type 2 diabetes progression has led to the development of therapies targeting the immune system. We develop a model of interleukin-1β dynamics in order to explain principles of disease onset. The parameters in the model are derived from in vitro experiments and patient data. In the framework of this model, an IL-1β switch is sufficient and necessary to account for type 2 diabetes onset. The model suggests that treatments targeting glucose ...[more]