Dataset Information

[18F]-fluorodeoxyglucose positron emission tomography can contribute to discriminate patients with poor prognosis in hormone receptor-positive breast cancer.

ABSTRACT:

Background

Patients with hormone receptor-positive breast cancer typically show favorable survival. However, identifying individuals at high risk of recurrence among these patients is a crucial issue. We tested the hypothesis that [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) scans can help predict prognosis in patients with hormone receptor-positive breast cancer.

Methods

Between April 2004 and December 2008, 305 patients with hormone receptor-positive breast cancer who underwent FGD-PET were enrolled. Patients with luminal B subtype were identified by positivity for human epidermal growth factor receptor-2 (HER2) or high Ki67 (?14%) according to criteria recently recommended by the St. Gallen panelists. The cut-off value of SUVmax was defined using the time-dependent receiver operator characteristic curve for recurrence-free survival (RFS).

Results

At a median follow up of 6.23 years, continuous SUVmax was a significant prognostic factor with a hazard ratio (HR) of 1.21 (p?=?0.021). The cut-off value of SUVmax was defined as 4. Patients with luminal B subtype (n?=?82) or high SUVmax (n?=?107) showed a reduced RFS (p?=?0.031 and 0.002, respectively). In multivariate analysis for RFS, SUVmax carried independent prognostic significance (p?=?0.012) whereas classification with immunohistochemical markers did not (p?=?0.274). The Harell c-index was 0.729. High SUVmax was significantly associated with larger tumor size, positive nodes, HER2 positivity, high Ki67 (?14%), high tumor grade, and luminal B subtype.

Conclusions

Among patients with hormone receptor-positive breast cancer, FDG-PET can help discriminate patients at high risk of tumor relapse.

SUBMITTER: Ahn SG

PROVIDER: S-EPMC4148332 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

[18F]-fluorodeoxyglucose positron emission tomography can contribute to discriminate patients with poor prognosis in hormone receptor-positive breast cancer.

Ahn Sung Gwe SG Lee Minkyung M Jeon Tae Joo TJ Han Kyunghwa K Lee Hak Min HM Lee Seung Ah SA Ryu Young Hoon YH Son Eun Ju EJ Jeong Joon J

PloS one 20140828 8

<h4>Background</h4>Patients with hormone receptor-positive breast cancer typically show favorable survival. However, identifying individuals at high risk of recurrence among these patients is a crucial issue. We tested the hypothesis that [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) scans can help predict prognosis in patients with hormone receptor-positive breast cancer.<h4>Methods</h4>Between April 2004 and December 2008, 305 patients with hormone receptor-positive breast ca ...[more]

PMID: 25167062

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Dataset Information

[18F]-fluorodeoxyglucose positron emission tomography can contribute to discriminate patients with poor prognosis in hormone receptor-positive breast cancer.

Background

Methods

Results

Conclusions

Publications

[18F]-fluorodeoxyglucose positron emission tomography can contribute to discriminate patients with poor prognosis in hormone receptor-positive breast cancer.

Similar Datasets

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