Ontology highlight
ABSTRACT:
SUBMITTER: Parr BT
PROVIDER: S-EPMC4149473 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Nature communications 20140801
Stereoselective synthesis of a cyclopentane nucleus by convergent annulation constitutes a significant challenge for synthetic chemists. Although a number of biologically relevant cyclopentane natural products are known, more often than not, the cyclopentane core is assembled in a stepwise manner because of the lack of efficient annulation strategies. Here we report the rhodium-catalysed reactions of vinyldiazoacetates with (E)-1,3-disubstituted 2-butenols generate cyclopentanes, containing four ...[more]