Ontology highlight
ABSTRACT:
SUBMITTER: Bordoli MR
PROVIDER: S-EPMC4149754 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Bordoli Mattia R MR Yum Jina J Breitkopf Susanne B SB Thon Jonathan N JN Italiano Joseph E JE Xiao Junyu J Worby Carolyn C Wong Swee-Kee SK Lin Grace G Edenius Maja M Keller Tracy L TL Asara John M JM Dixon Jack E JE Yeo Chang-Yeol CY Whitman Malcolm M
Cell 20140801 5
Although tyrosine phosphorylation of extracellular proteins has been reported to occur extensively in vivo, no secreted protein tyrosine kinase has been identified. As a result, investigation of the potential role of extracellular tyrosine phosphorylation in physiological and pathological tissue regulation has not been possible. Here, we show that VLK, a putative protein kinase previously shown to be essential in embryonic development, is a secreted protein kinase, with preference for tyrosine, ...[more]