Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Pozo J
PROVIDER: S-EPMC6135941 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
iScience 20180323
The tissue inhibitor of metalloproteinases 2 (TIMP-2) is a specific endogenous inhibitor of matrix metalloproteinase 2 (MMP-2), which is a key enzyme that degrades the extracellular matrix and promotes tumor cell invasion. Although the TIMP-2:MMP-2 complex controls proteolysis, the signaling mechanism by which the two proteins associate in the extracellular space remains unidentified. Here we report that TIMP-2 is phosphorylated outside the cell by secreted c-Src tyrosine kinase. As a consequenc ...[more]