Ontology highlight
ABSTRACT:
SUBMITTER: D'Alessio S
PROVIDER: S-EPMC4151217 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
D'Alessio Silvia S Correale Carmen C Tacconi Carlotta C Gandelli Alessandro A Pietrogrande Giovanni G Vetrano Stefania S Genua Marco M Arena Vincenzo V Spinelli Antonino A Peyrin-Biroulet Laurent L Fiocchi Claudio C Danese Silvio S
The Journal of clinical investigation 20140808 9
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) of unknown etiology that are associated with an aberrant mucosal immune response. Neoangiogenesis and vascular injury are observed in IBD along with increased lymphangiogenesis. While the pathogenic role of angiogenesis in IBD is well characterized, it is not clear how or if increased lymphangiogenesis promotes disease. Here, we determined that enhancing lymphangiogenesis and lymphatic function reduce ...[more]