Ontology highlight
ABSTRACT:
SUBMITTER: Shin EM
PROVIDER: S-EPMC4151228 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Shin Eun Myoung EM Hay Hui Sin HS Lee Moon Hee MH Goh Jen Nee JN Tan Tuan Zea TZ Sen Yin Ping YP Lim See Wee SW Yousef Einas M EM Ong Hooi Tin HT Thike Aye Aye AA Kong Xiangjun X Wu Zhengsheng Z Mendoz Earnest E Sun Wei W Salto-Tellez Manuel M Lim Chwee Teck CT Lobie Peter E PE Lim Yoon Pin YP Yap Celestial T CT Zeng Qi Q Sethi Gautam G Lee Martin B MB Tan Patrick P Goh Boon Cher BC Miller Lance D LD Thiery Jean Paul JP Zhu Tao T Gaboury Louis L Tan Puay Hoon PH Hui Kam Man KM Yip George Wai-Cheong GW Miyamoto Shigeki S Kumar Alan Prem AP Tergaonkar Vinay V
The Journal of clinical investigation 20140801 9
Despite advancement in breast cancer treatment, 30% of patients with early breast cancers experience relapse with distant metastasis. It is a challenge to identify patients at risk for relapse; therefore, the identification of markers and therapeutic targets for metastatic breast cancers is imperative. Here, we identified DP103 as a biomarker and metastasis-driving oncogene in human breast cancers and determined that DP103 elevates matrix metallopeptidase 9 (MMP9) levels, which are associated wi ...[more]