Ontology highlight
ABSTRACT:
SUBMITTER: Tian L
PROVIDER: S-EPMC4151829 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Tian Linjie L Choi Seung-Chul SC Murakami Yousuke Y Allen Joselyn J Morse Herbert C HC Qi Chen-Feng CF Krzewski Konrad K Coligan John E JE
Nature communications 20140101
Apoptotic cell (AC) clearance is essential for immune homeostasis. Here we show that mouse CD300f (CLM-1) recognizes outer membrane-exposed phosphatidylserine, and regulates the phagocytosis of ACs. CD300f accumulates in phagocytic cups at AC contact sites. Phosphorylation within CD300f cytoplasmic tail tyrosine-based motifs initiates signals that positively or negatively regulate AC phagocytosis. Y276 phosphorylation is necessary for enhanced CD300f-mediated phagocytosis through the recruitment ...[more]