In vitro antiplasmodial activity of cepharanthine.
Ontology highlight
ABSTRACT: Background
New classes of anti-malarial drugs are needed to control the alarming Plasmodium falciparum resistance toward current anti-malarial therapy. The ethnopharmacological approach allows the discovery of original chemical structures from the vegetable biodiversity. Previous studies led to the selection of a bisbenzylisoquinoline, called cepharanthine and isolated from a Cambodian plant: Stephania rotunda. Cepharanthine could exert a mechanism of action different from commonly used drugs. Potential plasmodial targets are reported here.Methods
To study the mechanism of action of cepharanthine, a combined approach using phenotypic and transcriptomic techniques was undertaken.Results
Cepharanthine blocked P. falciparum development in ring stage. On a culture of synchronized ring stage, the comparisons of expression profiles showed that the samples treated with 5 ?M of cepharanthine (IC90) were significantly closer to the initial controls than to the final ones. After a two-way ANOVA (p-value?ConclusionThe blockage at the ring stage by cepharanthine is described for the first time. Transcriptomic approach confirmed that cepharanthine might have a potential innovative antiplasmodial mechanism of action. Thus, cepharanthine might play an ongoing role in the progress on anti-malarial drug discovery efforts.
SUBMITTER: Desgrouas C
PROVIDER: S-EPMC4152577 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
In vitro antiplasmodial activity of cepharanthine.
Desgrouas Camille C Chapus Charles C Desplans Jérôme J Travaille Christelle C Pascual Aurélie A Baghdikian Béatrice B Ollivier Evelyne E Parzy Daniel D Taudon Nicolas N
Malaria journal 20140822
<h4>Background</h4>New classes of anti-malarial drugs are needed to control the alarming Plasmodium falciparum resistance toward current anti-malarial therapy. The ethnopharmacological approach allows the discovery of original chemical structures from the vegetable biodiversity. Previous studies led to the selection of a bisbenzylisoquinoline, called cepharanthine and isolated from a Cambodian plant: Stephania rotunda. Cepharanthine could exert a mechanism of action different from commonly used ...[more]
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