A New Alkamide with an Endoperoxide Structure from Acmella ciliata (Asteraceae) and Its in Vitro Antiplasmodial Activity.
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SUBMITTER: Silveira N
PROVIDER: S-EPMC6274185 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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A New Alkamide with an Endoperoxide Structure from Acmella ciliata (Asteraceae) and Its in Vitro Antiplasmodial Activity.
Silveira Narjara N Saar Julia J Santos Alan Diego C AD Barison Andersson A Sandjo Louis P LP Kaiser Marcel M Schmidt Thomas J TJ Biavatti Maique W MW
Molecules (Basel, Switzerland) 20160611 6
From the aerial parts of Acmella ciliata (H.B.K.) Cassini (basionym Spilanthes ciliata Kunth; Asteraceae), three alkamides were isolated and identified by mass- and NMR spectroscopic methods as (2E,6E,8E)-N-isobutyl-2,6,8-decatrienamide (spilanthol, (1)), N-(2-phenethyl)-2E-en-6,8-nonadiynamide (2) and (2E,7Z)-6,9-endoperoxy-N-isobutyl-2,7-decadienamide (3). While 1 and 2 are known alkamides, compound 3 has not been described until now. It was found that the unusual cyclic peroxide 3 exists as a ...[more]
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