Ontology highlight
ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC4152735 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Proline-directed phosphorylation is a posttranslational modification that is instrumental in regulating signaling from the plasma membrane to the nucleus, and its dysregulation contributes to cancer development. Protein interacting with never in mitosis A1 (Pin1), which is overexpressed in many types of cancer, isomerizes specific phosphorylated Ser/Thr-Pro bonds in many substrate proteins, including glycolytic enzyme, protein kinases, protein phosphatases, methyltransferase, lipid kinase, ubiqu ...[more]