Ontology highlight
ABSTRACT:
SUBMITTER: Pu W
PROVIDER: S-EPMC7136398 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pu Wenchen W Zheng Yuanyuan Y Peng Yong Y
Frontiers in cell and developmental biology 20200331
Peptidyl-prolyl <i>cis-trans</i> isomerase NIMA-interacting 1 (Pin1) is an evolutionally conserved and unique enzyme that specifically catalyzes the <i>cis-trans</i> isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif and, subsequently, induces the conformational change of its substrates. Mounting evidence has demonstrated that Pin1 is widely overexpressed and/or overactivated in cancer, exerting a critical influence on tumor initiation and progression via regulation of ...[more]