Ontology highlight
ABSTRACT:
SUBMITTER: Fong CS
PROVIDER: S-EPMC4116473 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Fong Chii Shyang CS Kim Minhee M Yang T Tony TT Liao Jung-Chi JC Tsou Meng-Fu Bryan MF
Developmental cell 20140710 2
Centrioles are 9-fold symmetric structures duplicating once per cell cycle. Duplication involves self-oligomerization of the centriolar protein SAS-6, but how the 9-fold symmetry is invariantly established remains unclear. Here, we found that SAS-6 assembly can be shaped by preexisting (or mother) centrioles. During S phase, SAS-6 molecules are first recruited to the proximal lumen of the mother centriole, adopting a cartwheel-like organization through interactions with the luminal wall, rather ...[more]