Ontology highlight
ABSTRACT:
SUBMITTER: Chamberlain CE
PROVIDER: S-EPMC4153699 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Chamberlain Chester E CE Scheel David W DW McGlynn Kathleen K Kim Hail H Miyatsuka Takeshi T Wang Juehu J Nguyen Vinh V Zhao Shuhong S Mavropoulos Anastasia A Abraham Aswin G AG O'Neill Eric E Ku Gregory M GM Cobb Melanie H MH Martin Gail R GR German Michael S MS
The Journal of clinical investigation 20140818 9
Endocrine cell proliferation fluctuates dramatically in response to signals that communicate hormone demand. The genetic alterations that override these controls in endocrine tumors often are not associated with oncogenes common to other tumor types, suggesting that unique pathways govern endocrine proliferation. Within the pancreas, for example, activating mutations of the prototypical oncogene KRAS drive proliferation in all pancreatic ductal adenocarcimomas but are never found in pancreatic e ...[more]