Ontology highlight
ABSTRACT:
SUBMITTER: Arnold C
PROVIDER: S-EPMC4154134 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Arnold Caroline C Feldner Anja A Pfisterer Larissa L Hödebeck Maren M Troidl Kerstin K Genové Guillem G Wieland Thomas T Hecker Markus M Korff Thomas T
EMBO molecular medicine 20140801 8
Arteriogenesis-the growth of collateral arterioles-partially compensates for the progressive occlusion of large conductance arteries as it may occur as a consequence of coronary, cerebral or peripheral artery disease. Despite being clinically highly relevant, mechanisms driving this process remain elusive. In this context, our study revealed that abundance of regulator of G-protein signalling 5 (RGS5) is increased in vascular smooth muscle cells (SMCs) of remodelling collateral arterioles. RGS5 ...[more]