Ontology highlight
ABSTRACT:
SUBMITTER: Liu ZJ
PROVIDER: S-EPMC140667 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Liu Zhao-Jun ZJ Shirakawa Takashi T Li Yan Y Soma Akinobu A Oka Masahiro M Dotto G Paolo GP Fairman Ronald M RM Velazquez Omaida C OC Herlyn Meenhard M
Molecular and cellular biology 20030101 1
Notch and its ligands play critical roles in cell fate determination. Expression of Notch and ligand in vascular endothelium and defects in vascular phenotypes of targeted mutants in the Notch pathway have suggested a critical role for Notch signaling in vasculogenesis and angiogenesis. However, the angiogenic signaling that controls Notch and ligand gene expression is unknown. We show here that vascular endothelial growth factor (VEGF) but not basic fibroblast growth factor can induce gene expr ...[more]