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RNAi therapies: drugging the undruggable.


ABSTRACT: RNA interference (RNAi) therapy is a rapidly emerging platform for personalized cancer treatment. Recent advances in small interfering RNA delivery and target selection provide unprecedented opportunities for clinical translation. Here, we discuss these advances and present strategies for making RNAi-based therapy a viable part of cancer management.

SUBMITTER: Wu SY 

PROVIDER: S-EPMC4154139 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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RNAi therapies: drugging the undruggable.

Wu Sherry Y SY   Lopez-Berestein Gabriel G   Calin George A GA   Calin George A GA   Sood Anil K AK  

Science translational medicine 20140601 240


RNA interference (RNAi) therapy is a rapidly emerging platform for personalized cancer treatment. Recent advances in small interfering RNA delivery and target selection provide unprecedented opportunities for clinical translation. Here, we discuss these advances and present strategies for making RNAi-based therapy a viable part of cancer management. ...[more]

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