Ontology highlight
ABSTRACT:
SUBMITTER: Cox AD
PROVIDER: S-EPMC4355017 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Cox Adrienne D AD Fesik Stephen W SW Kimmelman Alec C AC Luo Ji J Der Channing J CJ
Nature reviews. Drug discovery 20141017 11
Despite more than three decades of intensive effort, no effective pharmacological inhibitors of the RAS oncoproteins have reached the clinic, prompting the widely held perception that RAS proteins are 'undruggable'. However, recent data from the laboratory and the clinic have renewed our hope for the development of RAS-inhibitory molecules. In this Review, we summarize the progress and the promise of five key approaches. Firstly, we focus on the prospects of using direct inhibitors of RAS. Secon ...[more]