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Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma.


ABSTRACT: Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis at recurrence, and death compared with Group B patients. Identification and optimization of immunohistochemical (IHC) markers for PF ependymoma subgroups allowed validation of our findings on a third independent cohort, using a human ependymoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.

SUBMITTER: Witt H 

PROVIDER: S-EPMC4154494 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma.

Witt Hendrik H   Mack Stephen C SC   Ryzhova Marina M   Bender Sebastian S   Sill Martin M   Isserlin Ruth R   Benner Axel A   Hielscher Thomas T   Milde Till T   Remke Marc M   Jones David T W DT   Northcott Paul A PA   Garzia Livia L   Bertrand Kelsey C KC   Wittmann Andrea A   Yao Yuan Y   Roberts Stephen S SS   Massimi Luca L   Van Meter Tim T   Weiss William A WA   Gupta Nalin N   Grajkowska Wiesia W   Lach Boleslaw B   Cho Yoon-Jae YJ   von Deimling Andreas A   Kulozik Andreas E AE   Witt Olaf O   Bader Gary D GD   Hawkins Cynthia E CE   Tabori Uri U   Guha Abhijit A   Rutka James T JT   Lichter Peter P   Korshunov Andrey A   Taylor Michael D MD   Pfister Stefan M SM  

Cancer cell 20110801 2


Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are mu  ...[more]

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