Ontology highlight
ABSTRACT:
SUBMITTER: Witt H
PROVIDER: S-EPMC4154494 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Witt Hendrik H Mack Stephen C SC Ryzhova Marina M Bender Sebastian S Sill Martin M Isserlin Ruth R Benner Axel A Hielscher Thomas T Milde Till T Remke Marc M Jones David T W DT Northcott Paul A PA Garzia Livia L Bertrand Kelsey C KC Wittmann Andrea A Yao Yuan Y Roberts Stephen S SS Massimi Luca L Van Meter Tim T Weiss William A WA Gupta Nalin N Grajkowska Wiesia W Lach Boleslaw B Cho Yoon-Jae YJ von Deimling Andreas A Kulozik Andreas E AE Witt Olaf O Bader Gary D GD Hawkins Cynthia E CE Tabori Uri U Guha Abhijit A Rutka James T JT Lichter Peter P Korshunov Andrey A Taylor Michael D MD Pfister Stefan M SM
Cancer cell 20110801 2
Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are mu ...[more]