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Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae.

ABSTRACT: Malaria parasite transmission depends on the successful transition of Plasmodium through discrete developmental stages in the lumen of the mosquito midgut. Like the human intestinal tract, the mosquito midgut contains a diverse microbial flora, which may compromise the ability of Plasmodium to establish infection. We have identified an Enterobacter bacterium isolated from wild mosquito populations in Zambia that renders the mosquito resistant to infection with the human malaria parasite Plasmodium falciparum by interfering with parasite development before invasion of the midgut epithelium. Phenotypic analyses showed that the anti-Plasmodium mechanism requires small populations of replicating bacteria and is mediated through a mosquito-independent interaction with the malaria parasite. We show that this anti-Plasmodium effect is largely caused by bacterial generation of reactive oxygen species.

SUBMITTER: Cirimotich CM

PROVIDER: S-EPMC4154605 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae.

Cirimotich Chris M CM Dong Yuemei Y Clayton April M AM Sandiford Simone L SL Souza-Neto Jayme A JA Mulenga Musapa M Dimopoulos George G

Science (New York, N.Y.) 20110501 6031

Malaria parasite transmission depends on the successful transition of Plasmodium through discrete developmental stages in the lumen of the mosquito midgut. Like the human intestinal tract, the mosquito midgut contains a diverse microbial flora, which may compromise the ability of Plasmodium to establish infection. We have identified an Enterobacter bacterium isolated from wild mosquito populations in Zambia that renders the mosquito resistant to infection with the human malaria parasite Plasmodi ...[more]

PMID: 21566196

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