Ontology highlight
ABSTRACT:
SUBMITTER: Franks PW
PROVIDER: S-EPMC4154629 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Franks Paul W PW Christophi Costas A CA Jablonski Kathleen A KA Billings Liana K LK Delahanty Linda M LM Horton Edward S ES Knowler William C WC Florez Jose C JC
Diabetologia 20131207 3
<h4>Aims/hypothesis</h4>PPARGC1A and PPARGCB encode transcriptional coactivators that regulate numerous metabolic processes. We tested associations and treatment (i.e. metformin or lifestyle modification) interactions with metabolic traits in the Diabetes Prevention Program, a randomised controlled trial in persons at high risk of type 2 diabetes.<h4>Methods</h4>We used Tagger software to select 75 PPARGCA1 and 94 PPARGC1B tag single-nucleotide polymorphisms (SNPs) for analysis. These SNPs were ...[more]