Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line.
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ABSTRACT:
SUBMITTER: Mold M
PROVIDER: S-EPMC4155332 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line.
Mold Matthew M Eriksson Håkan H Siesjö Peter P Darabi Anna A Shardlow Emma E Exley Christopher C
Scientific reports 20140905
Aluminium-based adjuvants (ABA) are the predominant adjuvants used in human vaccinations. While a consensus is yet to be reached on the aetiology of the biological activities of ABA several studies have identified shape, crystallinity and size as critical factors affecting their adjuvanticity. In spite of recent advances, the fate of ABA following their administration remains unclear. Few if any studies have demonstrated the unequivocal presence of intracellular ABA. Herein we demonstrate for th ...[more]
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