Ontology highlight
ABSTRACT:
SUBMITTER: Cheung PP
PROVIDER: S-EPMC4155405 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nature communications 20140903
Genetic diversity of influenza A viruses (IAV) acquired through the error-prone RNA-dependent RNA polymerase (RdRP) or through genetic reassortment enables perpetuation of IAV in humans through epidemics or pandemics. Here, to assess the biological significance of genetic diversity acquired through RdRP, we characterize an IAV fidelity variant derived from passaging a seasonal H3N2 virus in the presence of ribavirin, a purine analogue that increases guanosine-to-adenosine mutations. We demonstra ...[more]